Restoring p53-Dependent Tumor Suppression
نویسندگان
چکیده
منابع مشابه
Restoring PML tumor suppression to combat cancer
Surmounting multiple tumor suppressive barriers is fundamental to cancer onset, but also predicts that their restoration may pose a powerful anticancer strategy. The proof of this principle has been elegantly demonstrated by the restoration of p53-induced tumor suppression (reviewed in ref. 1). The promyelocytic leukemia protein (PML) is emerging as a key tumor suppressor that is inactivated in...
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p53 is a pivotal tumor suppressor that induces apoptosis, cell-cycle arrest and senescence in response to stress signals. Although p53 transcriptional activation is important for these responses, the mechanisms underlying tumor suppression have been elusive. To date, no single or compound mouse knockout of specific p53 target genes has recapitulated the dramatic tumor predisposition that charac...
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Recent studies in human fibroblasts have provided a new general paradigm of tumor suppression according to which oncogenic signaling produces DNA damage and this, in turn, results in ATM/p53-dependent cellular senescence. Here, we have tested this model in a variety of murine experimental systems. Overexpression of oncogenic Ras in murine fibroblasts efficiently induced senescence but this occu...
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Mouse p53 is phosphorylated at Ser18 and Ser23 after DNA damage. To determine whether these two phosphorylation events have synergistic functions in activating p53 responses, we simultaneously introduced Ser18/23 to Ala mutations into the endogenous p53 locus in mice. While partial defects in apoptosis are observed in p53S18A and p53S23A thymocytes exposed to IR, p53-dependent apoptosis is esse...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2003
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.203